Альфа кислоты

Клинические исследования по изучению механизма действия и эффективности препаратов альфа кислот продолжаются. Мы предлагаем Вашему вниманию постоянно обновляемый список клинических исследований в этой области.



 Клинические исследования: альфа кислоты

Everard A, Geurts L, Van Roye M, Delzenne NM, Cani PD. Tetrahydro iso-Alpha Acids from Hops Improve Glucose Homeostasis and Reduce Body Weight Gain and 
Metabolic Endotoxemia in High-Fat Diet-Fed Mice. PLoS One. 2012;7(3):e33858. Epub 2012 Mar 28. PubMed PMID: 22470484; PubMed Central PMCID: PMC3314685.

Tsurumaru Y, Sasaki K, Miyawaki T, Uto Y, Momma T, Umemoto N, Momose M, Yazaki K. HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of
bitter acids in hops. Biochem Biophys Res Commun. 2012 Jan 6;417(1):393-8. Epub 2011 Dec 7. PubMed PMID: 22166201.

Saugspier M, Dorn C, Thasler WE, Gehrig M, Heilmann J, Hellerbrand C. Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro. Exp Mol Pathol. 2012 Apr;92(2):222-8. Epub 2011 Nov 25. PubMed PMID: 22146696.

Gatica-Arias A, Farag MA, Stanke M, Matoušek J, Wessjohann L, Weber G. Flavonoid production in transgenic hop (Humulus lupulus L.) altered by PAP1/MYB75 from Arabidopsis thaliana L. Plant Cell Rep. 2012 Jan;31(1):111-9. Epub 2011 Sep 13. PubMed PMID: 21912858.

Cattoor K, Remon JP, Boussery K, Van Bocxlaer J, Bracke M, De Keukeleire D, Deforce D, Heyerick A. Bioavailability of hop-derived iso-α-acids and reduced derivatives. Food Funct. 2011 Jul;2(7):412-22. Epub 2011 Jun 17. PubMed PMID: 21894329.

Gros J, Nizet S, Collin S. Occurrence of odorant polyfunctional thiols in the Super Alpha Tomahawk hop cultivar. Comparison with the thiol-rich Nelson Sauvin bitter variety. J Agric Food Chem. 2011 Aug 24;59(16):8853-65. Epub 2011 Jul 20. PubMed PMID: 21740044.

Lamb JJ, Holick MF, Lerman RH, Konda VR, Minich DM, Desai A, Chen TC, Austin M, Kornberg J, Chang JL, Hsi A, Bland JS, Tripp ML. Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₁ produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome. Nutr Res. 2011 May;31(5):347-55. Epub 2011 Apr 29. PubMed PMID: 21636012.

Intelmann D, Haseleu G, Dunkel A, Lagemann A, Stephan A, Hofmann T. Comprehensive sensomics analysis of hop-derived bitter compounds during storage of beer. J Agric Food Chem. 2011 Mar 9;59(5):1939-53. Epub 2011 Feb 8. PubMed PMID: 21302939.

Lerman RH, Minich DM, Darland G, Lamb JJ, Chang JL, Hsi A, Bland JS, Tripp ML. Subjects with elevated LDL cholesterol and metabolic syndrome benefit from
supplementation with soy protein, phytosterols, hops rho iso-alpha acids, and Acacia nilotica proanthocyanidins. J Clin Lipidol. 2010 Jan-Feb;4(1):59-68. Epub 
2009 Dec 3. PubMed PMID: 21122628. 

Minich DM, Lerman RH, Darland G, Babish JG, Pacioretty LM, Bland JS, Tripp ML. Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome. J Nutr Metab. 2010;2010. pii: 467316. Epub 2010 May 18. PubMed PMID: 20721358; PubMed Central PMCID: PMC2915809.

Patzak J, Nesvadba V, Krofta K, Henychova A, Marzoev AI, Richards K. Evaluation of genetic variability of wild hops (Humulus lupulus L.) in Canada and the Caucasus region by chemical and molecular methods. Genome. 2010 Jul;53(7):545-57. PubMed PMID: 20616876.

Babish JG, Pacioretty LM, Bland JS, Minich DM, Hu J, Tripp ML. Antidiabetic screening of commercial botanical products in 3T3-L1 adipocytes and db/db mice. J Med Food. 2010 Jun;13(3):535-47. PubMed PMID: 20521979.

Cattoor K, Bracke M, Deforce D, De Keukeleire D, Heyerick A. Transport of hop bitter acids across intestinal Caco-2 cell monolayers. J Agric Food Chem. 2010 Apr 14;58(7):4132-40. PubMed PMID: 20329731.

Jirásko R, Holcapek M, Vrublová E, Ulrichová J, Simánek V. Identification of new phase II metabolites of xanthohumol in rat in vivo biotransformation of hop extracts using high-performance liquid chromatography electrospray ionization tandem mass spectrometry. J Chromatogr A. 2010 Jun 18;1217(25):4100-8. Epub 2010 
Feb 25. PubMed PMID: 20227705.

Holick MF, Lamb JJ, Lerman RH, Konda VR, Darland G, Minich DM, Desai A, Chen TC, Austin M, Kornberg J, Chang JL, Hsi A, Bland JS, Tripp ML. Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial. J Bone Miner Metab. 2010 May;28(3):342-50. Epub 2009 Dec 19. PubMed PMID: 20024591.

Hazelwood LA, Walsh MC, Pronk JT, Daran JM. Involvement of vacuolar sequestration and active transport in tolerance of Saccharomyces cerevisiae to hop iso-alpha-acids. Appl Environ Microbiol. 2010 Jan;76(1):318-28. Epub 2009 Nov 13. PubMed PMID: 19915041; PubMed Central PMCID: PMC2798648.

Caballero I, Agut M, Armentia A, Blanco CA. Importance of tetrahydroiso alpha-acids to the microbiological stability of beer. J AOAC Int. 2009 Jul-Aug;92(4):1160-4. PubMed PMID: 19714985. 

Konda VR, Desai A, Darland G, Bland JS, Tripp ML. Rho iso-alpha acids from hops inhibit the GSK-3/NF-kappaB pathway and reduce inflammatory markers associated with bone and cartilage degradation. J Inflamm (Lond). 2009 Aug 27;6:26. PubMed PMID: 19712471; PubMed Central PMCID: PMC2743673.

Van Cleemput M, Heyerick A, Libert C, Swerts K, Philippé J, De Keukeleire D, Haegeman G, De Bosscher K. Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma. Mol Nutr Food Res. 2009 Sep;53(9):1143-55. PubMed PMID: 19655312.

Lupinacci E, Meijerink J, Vincken JP, Gabriele B, Gruppen H, Witkamp RF.Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocytechemo attractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. J Agric Food Chem. 2009 Aug 26;57(16):7274-81. PubMed PMID: 19634869.

Haseleu G, Intelmann D, Hofmann T. Identification and RP-HPLC-ESI-MS/MS quantitation of bitter-tasting beta-acid transformation products in beer. J Agric Food Chem. 2009 Aug 26;57(16):7480-9. PubMed PMID: 19627140.

Kornysova O, Stanius Z, Obelevicius K, Ragazinskiene O, Skrzydlewska E, Maruska A. Capillary zone electrophoresis method for determination of bitter (alpha- and beta-) acids in hop (Humulus lupulus L.) cone extracts. Adv Med Sci. 2009;54(1):41-6. PubMed PMID: 19581204.

Behr J, Vogel RF. Mechanisms of hop inhibition: hop ionophores. J Agric Food Chem. 2009 Jul 22;57(14):6074-81. PubMed PMID: 19537790.

Intelmann D, Haseleu G, Hofmann T. LC-MS/MS quantitation of hop-derived bitter compounds in beer using the ECHO technique. J Agric Food Chem. 2009 Feb 25;57(4):1172-82. PubMed PMID: 19199583.

Lerman RH, Minich DM, Darland G, Lamb JJ, Schiltz B, Babish JG, Bland JS, Tripp ML. Enhancement of a modified Mediterranean-style, low glycemic load diet with specific phytochemicals improves cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia in a randomized trial. Nutr Metab (Lond). 2008 Nov 4;5:29. PubMed PMID: 18983673; PubMed Central PMCID:
PMC2588603.

Teotico DG, Bischof JJ, Peng L, Kliewer SA, Redinbo MR. Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Mol Pharmacol. 2008 Dec;74(6):1512-20. Epub 2008 Sep 2. PubMed PMID: 18768384; PubMed Central PMCID: PMC2584763.

Kunimune T, Shellhammer TH. Foam-stabilizing effects and cling formation patterns of iso-alpha-acids and reduced iso-alpha-acids in lager beer. J Agric Food Chem. 2008 Sep 24;56(18):8629-34. Epub 2008 Aug 27. PubMed PMID: 18729457.

Jaskula B, Kafarski P, Aerts G, De Cooman L. A kinetic study on the isomerization of hop alpha-acids. J Agric Food Chem. 2008 Aug 13;56(15):6408-15. Epub 2008 Jul 4. PubMed PMID: 18598038.

Hall AJ, Babish JG, Darland GK, Carroll BJ, Konda VR, Lerman RH, Bland JS, Tripp ML. Safety, efficacy and anti-inflammatory activity of rho iso-alpha-acids from hops. Phytochemistry. 2008 May;69(7):1534-47. Epub 2008 Mar 20. PubMed PMID: 18358504.

Minich DM, Bland JS, Katke J, Darland G, Hall A, Lerman RH, Lamb J, Carroll B, Tripp M. Clinical safety and efficacy of NG440: a novel combination of rho iso-alpha acids from hops, rosemary, and oleanolic acid for inflammatory conditions. Can J Physiol Pharmacol. 2007 Sep;85(9):872-83. PubMed PMID: 18066133.

Leitgeb B, Kerényi A, Bogár F, Paragi G, Penke B, Rákhely G. Studying the structural properties of polyalanine and polyglutamine peptides. J Mol Model. 2007 Nov;13(11):1141-50. Epub 2007 Sep 6. PubMed PMID: 17805586.

Schwekendiek A, Spring O, Heyerick A, Pickel B, Pitsch NT, Peschke F, de Keukeleire D, Weber G. Constitutive expression of a grapevine stilbene synthase gene in transgenic hop (Humulus lupulus L.) yields resveratrol and its derivatives in substantial quantities. J Agric Food Chem. 2007 Aug 22;55(17):7002-9. Epub 2007 Jul 26. PubMed PMID: 17655245.

Khatib A, Wilson EG, Kim HK, Supardi M, Choi YH, Verpoorte R. NMR assignment of iso-alpha-acids from isomerised extracts of Humulus lupulus L. cones. Phytochem Anal. 2007 Sep;18(5):371-7. PubMed PMID: 17624889.

Lamy V, Roussi S, Chaabi M, Gossé F, Schall N, Lobstein A, Raul F. Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis. 2007 Jul;28(7):1575-81. Epub 2007 Apr 13. PubMed PMID: 17434926.

Fratti RA, Collins KM, Hickey CM, Wickner W. Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification. J Biol Chem. 2007 May 18;282(20):14861-7. Epub 2007 Mar 30. PubMed PMID: 17400548.

Behr J, Israel L, Gänzle MG, Vogel RF. Proteomic approach for characterization of hop-inducible proteins in Lactobacillus brevis. Appl Environ Microbiol. 2007 May;73(10):3300-6. Epub 2007 Mar 16. PubMed PMID: 17369340; PubMed Central PMCID: PMC1907096.

Keukeleire JD, Janssens I, Heyerick A, Ghekiere G, Cambie J, Roldan-Ruiz I, Bockstaele EV, Keukeleire DD. Relevance of organic farming and effect of climatological conditions on the formation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol in hop (Humulus lupulus L.). J Agric Food Chem. 2007 Jan 10;55(1):61-6. PubMed PMID: 17199314.

Kac J, Vovk T. Sensitive electrochemical detection method for alpha-acids, beta-acids and xanthohumol in hops (Humulus lupulus L.). J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 1;850(1-2):531-7. Epub 2006 Dec 4. PubMed PMID: 17142112.

Schiller H, Forster A, Vonhoff C, Hegger M, Biller A, Winterhoff H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006 Sep;13(8):535-41. Epub 2006 Jul 24. PubMed PMID: 16860977.

Cardoso DR, Olsen K, Møller JK, Skibsted LH. Phenol and terpene quenching of singlet- and triplet-excited states of riboflavin in relation to light-struck flavor formation in beer. J Agric Food Chem. 2006 Jul 26;54(15):5630-6. Erratum in: J Agric Food Chem. 2006 Nov 29;54(24):9278. PubMed PMID: 16848556.

García-Villalba R, Cortacero-Ramírez S, Segura-Carretero A, Martín-Lagos Contreras JA, Fernández-Gutiérrez A. Analysis of hop acids and their oxidized derivatives and iso-alpha-acids in beer by capillary electrophoresis-electrospray ionization mass spectrometry. J Agric Food Chem. 2006 Jul 26;54(15):5400-9. PubMed PMID: 16848524.

Cerenak A, Satovic Z, Javornik B. Genetic mapping of hop (Humulus lupulus L.) applied to the detection of QTLs for alpha-acid content. Genome. 2006 May;49(5):485-94. PubMed PMID: 16767173.

Arráez-Román D, Cortacero-Ramírez S, Segura-Carretero A, Martín-Lagos Contreras JA, Fernández-Gutiérrez A. Characterization of the methanolic extract of hops using capillary electrophoresis-electrospray ionization-mass spectrometry. Electrophoresis. 2006 Jun;27(11):2197-207. PubMed PMID: 16639703.

Lukaczer D, Darland G, Tripp M, Liska D, Lerman RH, Schiltz B, Bland JS. A pilot trial evaluating Meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia. Phytother Res. 2005 Oct;19(10):864-9. PubMed PMID: 16261517.

Zanoli P, Rivasi M, Zavatti M, Brusiani F, Baraldi M. New insight in the neuropharmacological activity of Humulus lupulus L. J Ethnopharmacol. 2005 Oct 31;102(1):102-6. PubMed PMID: 16046089.

Gerhäuser C. Beer constituents as potential cancer chemopreventive agents. Eur J Cancer. 2005 Sep;41(13):1941-54. Review. PubMed PMID: 15953717.

Malowicki MG, Shellhammer TH. Isomerization and degradation kinetics of hop (Humulus lupulus) acids in a model wort-boiling system. J Agric Food Chem. 2005 Jun 1;53(11):4434-9. PubMed PMID: 15913306.

Yajima H, Ikeshima E, Shiraki M, Kanaya T, Fujiwara D, Odai H, Tsuboyama-Kasaoka N, Ezaki O, Oikawa S, Kondo K. Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance. J Biol Chem. 2004 Aug 6;279(32):33456-62. Epub 2004 Jun 3. PubMed PMID: 15178687.

Yansanjav A, Siegumfeldt H, Jespersen L, Vancanneyt M, Swings J, Hollerová I, Leisner JJ. Detection of resistance of lactic acid bacteria to a mixture of the hop analogue compounds tetrahydroiso-alpha-acids by noninvasive measurement of intracellular pH. J Appl Microbiol. 2004;96(6):1324-32. PubMed PMID: 15139925.

De Villiers A, Vanhoenacker G, Lynen F, Sandra P. Stir bar sorptive extraction-liquid desorption applied to the analysis of hop-derived bitter acids in beer by micellar electrokinetic chromatography. Electrophoresis. 2004 Feb;25(4-5):664-9. PubMed PMID: 14981694.

Zhang X, Liang X, Xiao H, Xu Q. Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J Am Soc Mass Spectrom. 2004 Feb;15(2):180-7. PubMed PMID: 14766285.

Chen WJ, Lin JK. Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascades. J Agric Food Chem. 2004 Jan 14;52(1):55-64. PubMed PMID: 14709013.

Buckwold VE, Wilson RJ, Nalca A, Beer BB, Voss TG, Turpin JA, Buckheit RW 3rd, Wei J, Wenzel-Mathers M, Walton EM, Smith RJ, Pallansch M, Ward P, Wells J, Chuvala L, Sloane S, Paulman R, Russell J, Hartman T, Ptak R. Antiviral activity of hop constituents against a series of DNA and RNA viruses. Antiviral Res. 2004 Jan;61(1):57-62. PubMed PMID: 14670594.

Sakamoto K, Konings WN. Beer spoilage bacteria and hop resistance. Int J Food Microbiol. 2003 Dec 31;89(2-3):105-24. Review. PubMed PMID: 14623377.

De Keukeleire J, Ooms G, Heyerick A, Roldan-Ruiz I, Van Bockstaele E, De Keukeleire D. Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.). J Agric Food Chem. 2003 Jul 16;51(15):4436-41. PubMed PMID: 12848522.

Hampton R, Nickerson G, Whitney P, Haunold A. Comparative chemical attributes of native North American hop, Humulus lupulus var. lupuloides E. Small. Phytochemistry. 2002 Dec;61(7):855-62. Erratum in: Phytochemistry. 2003 Jul;63(6):737-738. PubMed PMID: 12453579.

Burns CS, Heyerick A, De Keukeleire D, Forbes MD. Mechanism for formation of the lightstruck flavor in beer revealed by time-resolved electron paramagnetic resonance. Chemistry. 2001 Nov 5;7(21):4553-61. PubMed PMID: 11757646.

Hoek AC, Hermans-Lokkerbol AC, Verpoorte R. An improved NMR method for the quantification of alpha-acids in hops and hop products. Phytochem Anal. 2001 Jan-Feb;12(1):53-7. PubMed PMID: 11704962.

Paniego NB, Zuurbier KW, Fung SY, van der Heijden R, Scheffer JJ, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. Eur J Biochem. 1999 Jun;262(2):612-6. PubMed PMID: 10336650.

Chappel CI, Smith SY, Chagnon M. Subchronic toxicity study of tetrahydroisohumulone and hexahydroisohumulone in the beagle dog. Food Chem Toxicol. 1998 Nov;36(11):915-22. PubMed PMID: 9771552.

Hänsel R, Wohlfart R, Schmidt H. [The sedativ-hypnotic principle of hops]. Planta Med. 1982 Aug;45(4):224-8. German. PubMed PMID: 17396916.