Коэнзим Q10

Клинические исследования по изучению механизма действия и эффективности препаратов коэнзима Q10 продолжаются. Мы предлагаем Вашему вниманию постоянно обновляемый список клинических исследований в этой области.



 Клинические исследования: коэнзим Q10

CINRG pilot trial of coenzyme Q10 in steroid-treated Duchenne muscular dystrophy. Spurney CF, Rocha CT, Henricson E, Florence J, Mayhew J, Gorni K, Pasquali L, Pestronk A, Martin GR, Hu F, Nie L, Connolly AM, Escolar DM; Cooperative International Neuromuscular Research Group Investigators. Muscle Nerve. 2011 Aug;44(2):174-8. doi: 10.1002/mus.22047. Epub 2011 Jun 22. PMID: 21698649.

Prophylaxis of ischemic heart lesions during chronic heart failure with complex therapy using Q10 coenzyme. Shilov AM, Mel'nik MV, Voevodina ES, Osiia AO, Griaznov DA. Anesteziol Reanimatol. 2011 Mar-Apr;(2):34-8. Russian. PMID: 21692219.

Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? Case series with 5 patients. Cordero MD, Alcocer-Gómez E, de Miguel M, Cano-García FJ, Luque CM, Fernández-Riejo P, Fernández AM, Sánchez-Alcazar JA. Mitochondrion. 2011 Jul;11(4):623-5. Epub 2011 Apr 7. PMID: 21496502.

Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women. Cooney RV, Dai Q, Gao YT, Chow WH, Franke AA, Shu XO, Li H, Ji B, Cai Q, Chai W, Zheng W. Cancer Epidemiol Biomarkers Prev. 2011 Jun;20(6):1124-30. Epub 2011 Apr 5. PMID: 21467235.

Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study. Fumagalli S, Fattirolli F, Guarducci L, Cellai T, Baldasseroni S, Tarantini F, Di Bari M, Masotti G, Marchionni N. Clin Cardiol. 2011 Apr;34(4):211-7. doi: 10.1002/clc.20846. PMID: 21462215.

Effects of coenzyme Q10 on salivary secretion. Ryo K, Ito A, Takatori R, Tai Y, Arikawa K, Seido T, Yamada T, Shinpo K, Tamaki Y, Fujii K, Yamamoto Y, Saito I. Clin Biochem. 2011 Jun;44(8-9):669-74. Epub 2011 Mar 22. PMID: 21406193.

Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study. Lee YJ, Cho WJ, Kim JK, Lee DC. J Med Food. 2011 Apr;14(4):386-90. Epub 2011 Mar 3. PMID: 21370966.

Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. Shojaei M, Djalali M, Khatami M, Siassi F, Eshraghian M. Iran J Kidney Dis. 2011 Mar;5(2):114-8. PMID: 21368390. 

Coenzyme Q10 in combination with steroid therapy for treatment of sudden sensorineural hearing loss: a controlled prospective study. Ahn JH, Yoo MH, Lee HJ, Chung JW, Yoon TH. Clin Otolaryngol. 2010 Dec;35(6):486-9. doi: 10.1111/j.1749-4486.2010.02201.x. PMID: 21199410.

Water-soluble coenzyme Q10 formulation in presbycusis: long-term effects. Guastini L, Mora R, Dellepiane M, Santomauro V, Giorgio M, Salami A. Acta Otolaryngol. 2011 May;131(5):512-7. Epub 2010 Dec 16. PMID: 21162656.

Preservation of micronutrients during rapeseed oil refining: a tool to optimize the health value of edible vegetable oils? Rationale and design of the Optim'Oils randomized clinical trial. Gladine C, Meunier N, Blot A, Bruchet L, Pagès X, Gaud M, Floter E, Metin Z, Rossignol A, Cano N, Chardigny JM. Contemp Clin Trials. 2011 Mar;32(2):233-9. Epub 2010 Nov 10. PMID: 21073981.

Investigation of Pycnogenol® in combination with coenzymeQ10 in heart failure patients (NYHA II/III). Belcaro G, Cesarone MR, Dugall M, Hosoi M, Ippolito E, Bavera P, Grossi MG. Panminerva Med. 2010 Jun;52(2 Suppl 1):21-5. PMID: 20657530.

Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis. Sagel SD, Sontag MK, Anthony MM, Emmett P, Papas KA. J Cyst Fibros. 2011 Jan;10(1):31-6. Epub 2010 Oct 20. PMID: 20961818.

A randomized trial of coenzyme Q10 in mitochondrial disorders. Glover EI, Martin J, Maher A, Thornhill RE, Moran GR, Tarnopolsky MA. Muscle Nerve. 2010 Nov;42(5):739-48. PMID: 20886510.

Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure). McMurray JJ, Dunselman P, Wedel H, Cleland JG, Lindberg M, Hjalmarson A, Kjekshus J, Waagstein F, Apetrei E, Barrios V, Böhm M, Kamenský G, Komajda M, Mareev V, Wikstrand J; CORONA Study Group. J Am Coll Cardiol. 2010 Oct 5;56(15):1196-204. PMID: 20883926.

Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study. Esposito M, Carotenuto M. Neurol Sci. 2011 Feb;32(1):79-81. Epub 2010 Sep 25. PMID: 20872034.

Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study. Safarinejad MR. Int J Impot Res. 2010 Sep-Oct;22(5):298-309. Epub 2010 Aug PMID: 20720560.

Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial. Leong JY, van der Merwe J, Pepe S, Bailey M, Perkins A, Lymbury R, Esmore D, Marasco S, Rosenfeldt F. Heart Lung Circ. 2010 Oct;19(10):584-91. Epub 2010 Aug 2. PMID: 20674497.

Coenzyme Q(10)-responsive ataxia: 2-year-treatment follow-up. Pineda M, Montero R, Aracil A, O'Callaghan MM, Mas A, Espinos C, Martinez-Rubio D, Palau F, Navas P, Briones P, Artuch R. Mov Disord. 2010 Jul 15;25(9):1262-8. PMID: 20629161.

Complementary therapy in diabetic patients with chronic complications: a pilot study. Palacka P, Kucharska J, Murin J, Dostalova K, Okkelova A, Cizova M, Waczulikova I, Moricova S, Gvozdjakova A. Bratisl Lek Listy. 2010;111(4):205-11. PMID: 20586147.

Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect. Pardeike J, Schwabe K, Müller RH. Int J Pharm. 2010 Aug 30;396(1-2):166-73. Epub 2010 Jun 9. PMID: 20541000.

Water-soluble coenzyme Q10 formulation (Q-TER(®)) in the treatment of presbycusis. Salami A, Mora R, Dellepiane M, Manini G, Santomauro V, Barettini L, Guastini L. Acta Otolaryngol. 2010 Oct;130(10):1154-62. PMID: 20443731.

Atorvastatin increases blood ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein cholesterol in hypercholesterolemic patients. Liu CS, Lii CK, Chang LL, Kuo CL, Cheng WL, Su SL, Tsai CW, Chen HW. Nutr Res. 2010 Feb;30(2):118-24. PMID: 20226997.

Improved survival in patients with end-stage cancer treated with coenzyme Q(10) and other antioxidants: a pilot study. Hertz N, Lister RE. J Int Med Res. 2009 Nov-Dec;37(6):1961-71. Erratum in: J Int Med Res. 2010 Jan-Feb;38(1):293. PMID: 20146896.

Effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6, and tumor necrosis factor-alpha levels in men. Gökbel H, Gergerlioğlu HS, Okudan N, Gül I, Büyükbaş S, Belviranli M. J Med Food. 2010 Feb;13(1):216-8. PMID: 20136458.

Clinical study of Wenxikeli treatment of viral myocarditis]. Sun HY. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Apr;23(2):144-5. Chinese. PMID: 20104762.

Why did high-dose rosuvastatin not improve cardiac remodeling in chronic heart failure? Mechanistic insights from the UNIVERSE study. Ashton E, Windebank E, Skiba M, Reid C, Schneider H, Rosenfeldt F, Tonkin A, Krum H. Int J Cardiol. 2011 Feb 3;146(3):404-7. Epub 2010 Jan 20. PMID: 20085851.

Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy. Sacconi S, Trevisson E, Salviati L, Aymé S, Rigal O, Redondo AG, Mancuso M, Siciliano G, Tonin P, Angelini C, Auré K, Lombès A, Desnuelle C. Neuromuscul Disord. 2010 Jan;20(1):44-8. Epub 2009 Nov 27. PMID: 19945282.

The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects: a pilot study. Fetoni AR, Garzaro M, Ralli M, Landolfo V, Sensini M, Pecorari G, Mordente A, Paludetti G, Giordano C. Med Sci Monit. 2009 Nov;15(11):PR1-8. PMID: 19865065.

Evaluation of the antioxidant effect of a new functional food enriched with Sideritis euboea in healthy subjects. Skouroliakou M, Kastanidou O, Stathopoulou M, Vourli G. J Med Food. 2009 Oct;12(5):1105-10. PMID: 19857076.

Assessment of the effectiveness of a sublingual, ergogenic spray on muscle strength and power. Jacobson BH, Smith DB, Warren AJ, Glass RG, Kline C, Fedick JL, Stemm J. J Strength Cond Res. 2009 Nov;23(8):2326-30. PMID: 19826292.

Progressive augmentation and ventilatory long-term facilitation are enhanced in sleep apnoea patients and are mitigated by antioxidant administration. Lee DS, Badr MS, Mateika JH. J Physiol. 2009 Nov 15;587(Pt 22):5451-67. Epub 2009 Oct 5. PMID: 19805747.

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III. Kaufmann P, Thompson JL, Levy G, Buchsbaum R, Shefner J, Krivickas LS, Katz J, Rollins Y, Barohn RJ, Jackson CE, Tiryaki E, Lomen-Hoerth C, Armon C, Tandan R, Rudnicki SA, Rezania K, Sufit R, Pestronk A, Novella SP, Heiman-Patterson T, Kasarskis EJ, Pioro EP, Montes J, Arbing R, Vecchio D, Barsdorf A, Mitsumoto H, Levin B; QALS Study Group. Ann Neurol. 2009 Aug;66(2):235-44. PMID: 19743457. 

Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. D'Andrea G, Bussone G, Allais G, Aguggia M, D'Onofrio F, Maggio M, Moschiano F, Saracco MG, Terzi MG, Petretta V, Benedetto C. Neurol Sci. 2009 May;30 Suppl 1:S121-4. PMID: 19415441.

The effects of [omega]3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial. Mori TA, Burke V, Puddey I, Irish A, Cowpland CA, Beilin L, Dogra G, Watts GF. J Hypertens. 2009 Sep;27(9):1863-72. PMID: 19705518.

Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy. Kocharian A, Shabanian R, Rafiei-Khorgami M, Kiani A, Heidari-Bateni G. Cardiol Young. 2009 Sep;19(5):501-6. Epub 2009 Aug 25. PMID: 19703336.

The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. Gökbel H, Gül I, Belviranl M, Okudan N. J Strength Cond Res. 2010 Jan;24(1):97-102. PMID: 19644406.

Determinants of the timing of symptomatic treatment in early Parkinson disease: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) Experience. Parashos SA, Swearingen CJ, Biglan KM, Bodis-Wollner I, Liang GS, Ross GW, Tilley BC, Shulman LM; NET-PD Investigators. Arch Neurol. 2009 Sep;66(9):1099-104. Epub 2009 Jul 13. PMID: 19597081.

Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. Safarinejad MR. J Urol. 2009 Jul;182(1):237-48. Epub 2009 May 17. PMID: 19447425.

Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system. Liu ZX, Artmann C. Altern Ther Health Med. 2009 Mar-Apr;15(2):42-6. PMID: 19284181.

Comparison of bioavailability of two ubidecarenone products in healthy Korean volunteers. Kang EY, Choi JW, Gwak HS, Chun IK. Int J Clin Pharmacol Ther. 2009 Mar;47(3):207-14. PMID: 19281730.

Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Hamilton SJ, Chew GT, Watts GF. Diabetes Care. 2009 May;32(5):810-2. Epub 2009 Feb 19. PMID: 19228872.

Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Teran E, Hernandez I, Nieto B, Tavara R, Ocampo JE, Calle A. Int J Gynaecol Obstet. 2009 Apr;105(1):43-5. Epub 2009 Jan 19. PMID: 19154996.

Supplemental ubiquinol in patients with advanced congestive heart failure. Langsjoen PH, Langsjoen AM. Biofactors. 2008;32(1-4):119-28. PMID: 19096107.

Coenzyme Q10 and vitamin E deficiency in Friedreich's ataxia: predictor of efficacy of vitamin E and coenzyme Q10 therapy. Cooper JM, Korlipara LV, Hart PE, Bradley JL, Schapira AH. Eur J Neurol. 2008 Dec;15(12):1371-9. PMID: 19049556.

Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation to psoriasis patients. Kharaeva Z, Gostova E, De Luca C, Raskovic D, Korkina L. Nutrition. 2009 Mar;25(3):295-302. Epub 2008 Nov 28. PMID: 19041224.

Effects of resistance training in combination with coenzyme Q10 supplementation in patients with post-polio: a pilot study. Skough K, Krossén C, Heiwe S, Theorell H, Borg K. J Rehabil Med. 2008 Oct;40(9):773-5. PMID: 18843432.

The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery. Makhija N, Sendasgupta C, Kiran U, Lakshmy R, Hote MP, Choudhary SK, Airan B, Abraham R. J Cardiothorac Vasc Anesth. 2008 Dec;22(6):832-9. Epub 2008 Jun 6. PMID: 18834786.

Influence of CoQ10 on autonomic nervous activity and energy metabolism during exercise in healthy subjects. Zheng A, Moritani T. J Nutr Sci Vitaminol (Tokyo). 2008 Aug;54(4):286-90. PMID: 18797149.

Supplementation with an antioxidant cocktail containing coenzyme Q prevents plasma oxidative damage induced by soccer. Tauler P, Ferrer MD, Sureda A, Pujol P, Drobnic F, Tur JA, Pons A. Eur J Appl Physiol. 2008 Nov;104(5):777-85. Epub 2008 Jul 30. PMID: 18665388.

Relative bioavailability of two forms of a novel water-soluble coenzyme Q10. Zmitek J, Smidovnik A, Fir M, Prosek M, Zmitek K, Walczak J, Pravst I. Ann Nutr Metab. 2008;52(4):281-7. Epub 2008 Jul 22. PMID: 18645245.

The relationship between CAG repeat length and clinical progression in Huntington's disease. Ravina B, Romer M, Constantinescu R, Biglan K, Brocht A, Kieburtz K, Shoulson I, McDermott MP. Mov Disord. 2008 Jul 15;23(9):1223-7. PMID: 18512767.

Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. Sakata T, Furuya R, Shimazu T, Odamaki M, Ohkawa S, Kumagai H. Blood Purif. 2008;26(4):371-8. Epub 2008 May 29. PMID: 18509244.

Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction. Chew GT, Watts GF, Davis TM, Stuckey BG, Beilin LJ, Thompson PL, Burke V, Currie PJ. Diabetes Care. 2008 Aug;31(8):1502-9. Epub 2008 May 16. PMID: 18487480.

Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial. Stamelou M, Reuss A, Pilatus U, Magerkurth J, Niklowitz P, Eggert KM, Krisp A, Menke T, Schade-Brittinger C, Oertel WH, Höglinger GU. Mov Disord. 2008 May 15;23(7):942-9. PMID: 18464278.

Anti-angiogenic potential of CoenzymeQ10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy. Premkumar VG, Yuvaraj S, Sathish S, Shanthi P, Sachdanandam P. Vascul Pharmacol. 2008 Apr-Jun;48(4-6):191-201. Epub 2008 Mar 5. PMID: 18407793.

Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, Ricciardo-Lamonica G, Boscaro M, Lenzi A, Littarru G. Fertil Steril. 2009 May;91(5):1785-92. Epub 2008 Apr 8. PMID: 18395716.

Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. Premkumar VG, Yuvaraj S, Shanthi P, Sachdanandam P. Br J Nutr. 2008 Dec;100(6):1179-82. PMID: 18377693.

Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, Okamoto T, Kono I. Br J Nutr. 2008 Oct;100(4):903-9. Epub 2008 Feb 20. PMID: 18284711.

Antifatigue effects of coenzyme Q10 during physical fatigue. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y. Nutrition. 2008 Apr;24(4):293-9. Epub 2008 Feb 13. Erratum in: Nutrition. 2008 Jun;24(6):616. PMID: 18272335.

The effect of coenzyme Q10 on microcirculatory endothelial function of subjects with type 2 diabetes mellitus. Lim SC, Lekshminarayanan R, Goh SK, Ong YY, Subramaniam T, Sum CF, Ong CN, Lee BL. Atherosclerosis. 2008 Feb;196(2):966-9. Epub 2007 Dec 31.  PMID: 18164307.

Increase of bioavailability of coenzyme Q(10) and vitamin E. Wajda R, Zirkel J, Schaffer T. J Med Food. 2007 Dec;10(4):731-4. PMID: 18158850.

Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Miles MV, Patterson BJ, Chalfonte-Evans ML, Horn PS, Hickey FJ, Schapiro MB, Steele PE, Tang PH, Hotze SL. Pediatr Neurol. 2007 Dec;37(6):398-403. PMID: 18021919.

Comparison of effects of pitavastatin and atorvastatin on plasma coenzyme Q10 in heterozygous familial hypercholesterolemia: results from a crossover study. Kawashiri MA, Nohara A, Tada H, Mori M, Tsuchida M, Katsuda S, Inazu A, Kobayashi J, Koizumi J, Mabuchi H, Yamagishi M. Clin Pharmacol Ther. 2008 May;83(5):731-9. Epub 2007 Oct 24. PMID: 17957184.

Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia. Young JM, Florkowski CM, Molyneux SL, McEwan RG, Frampton CM, George PM, Scott RS. Am J Cardiol. 2007 Nov 1;100(9):1400-3. Epub 2007 Aug 16. PMID: 17950797.

A randomized study of the bioavailability of different formulations of coenzyme Q(10) (ubiquinone). Constantinescu R, McDermott MP, Dicenzo R, de Blieck EA, Hyson HC, Beal MF, Bednarczyk EM, Bogdanov M, Metakis LJ, Browne SE, Lorenzo BJ, Ravina B, Kieburtz K. J Clin Pharmacol. 2007 Dec;47(12):1580-6. Epub 2007 Oct 9.  PMID: 17925590.

Safety assessment of PureSorb-Q40 in healthy subjects and serum coenzyme Q10 level in excessive dosing. Nuku K, Matsuoka Y, Yamagishi T, Miyawaki H, Sato K. J Nutr Sci Vitaminol (Tokyo). 2007 Jun;53(3):198-206. PMID: 17874823.

Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis. Shalansky S, Lynd L, Richardson K, Ingaszewski A, Kerr C. Pharmacotherapy. 2007 Sep;27(9):1237-47. PMID: 17723077.

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Mabuchi H, Nohara A, Kobayashi J, Kawashiri MA, Katsuda S, Inazu A, Koizumi J; Hokuriku Lipid Research Group. Atherosclerosis. 2007 Dec;195(2):e182-9. Epub 2007 Aug 6. PMID: 17681347.

Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. Tiano L, Belardinelli R, Carnevali P, Principi F, Seddaiu G, Littarru GP. Eur Heart J. 2007 Sep;28(18):2249-55. Epub 2007 Jul 19. PMID: 17644511.

Comparison of uptake between PureSorb-Q40 and regular hydrophobic coenzyme Q10 in rats and humans after single oral intake. Nukui K, Yamagishi T, Miyawaki H, Kettawan A, Okamoto T, Sato K. J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):187-90. PMID: 17616008.

Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin. Premkumar VG, Yuvaraj S, Vijayasarathy K, Gangadaran SG, Sachdanandam P. Basic Clin Pharmacol Toxicol. 2007 Jun;100(6):387-91. PMID: 17516992.

Recombinant interferon alpha-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-alpha and 5-year follow-up. Rusciani L, Proietti I, Paradisi A, Rusciani A, Guerriero G, Mammone A, De Gaetano A, Lippa S. Melanoma Res. 2007 Jun;17(3):177-83. PMID: 17505263.

Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. Storch A, Jost WH, Vieregge P, Spiegel J, Greulich W, Durner J, Müller T, Kupsch A, Henningsen H, Oertel WH, Fuchs G, Kuhn W, Niklowitz P, Koch R, Herting B, Reichmann H; German Coenzyme Q(10) Study Group. Arch Neurol. 2007 Jul;64(7):938-44. Epub 2007 May 14. PMID: 17502459. 

Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. Caso G, Kelly P, McNurlan MA, Lawson WE. Am J Cardiol. 2007 May 15;99(10):1409-12. Epub 2007 Apr 3. PMID: 17493470.

Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. Niklowitz P, Sonnenschein A, Janetzky B, Andler W, Menke T. Int J Biol Sci. 2007 Apr 5;3(4):257-62. PMID: 17479158. 

Coenzyme Q10 in patients undergoing CABG: Effect of statins and nutritional supplementation. Keith M, Mazer CD, Mikhail P, Jeejeebhoy F, Briet F, Errett L. Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):105-11. Epub 2007 Mar 26. PMID: 17368873.

Excellent inter-rater, intra-rater, and telephone-administered reliability of the ALSFRS-R in a multicenter clinical trial. Kaufmann P, Levy G, Montes J, Buchsbaum R, Barsdorf AI, Battista V, Arbing R, Gordon PH, Mitsumoto H, Levin B, Thompson JL; QALS study group. Amyotroph Lateral Scler. 2007 Feb;8(1):42-6. PMID: 17364435.

Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Hershey AD, Powers SW, Vockell AL, Lecates SL, Ellinor PL, Segers A, Burdine D, Manning P, Kabbouche MA. Headache. 2007 Jan;47(1):73-80. PMID: 17355497.

Electrocardiographic and hemodynamic effects of coenzyme Q10 in healthy individuals: a double-blind, randomized controlled trial. Shah SA, Sander S, Cios D, Lipeika J, Kluger J, White CM. Ann Pharmacother. 2007 Mar;41(3):420-5. Epub 2007 Mar 6. PMID: 17341532.

Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy. Premkumar VG, Yuvaraj S, Vijayasarathy K, Gangadaran SG, Sachdanandam P. Biol Pharm Bull. 2007 Feb;30(2):367-70. PMID: 17268082.

A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Khan M, Gross J, Haupt H, Jainz A, Niklowitz P, Scherer H, Schmidt FP, Klapp BF, Reisshauer A, Mazurek B. Otolaryngol Head Neck Surg. 2007 Jan;136(1):72-7. PMID: 17210337.

A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. NINDS NET-PD Investigators. Neurology. 2007 Jan 2;68(1):20-8. PMID: 17200487.

Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10). Schulz C, Obermüller-Jevic UC, Hasselwander O, Bernhardt J, Biesalski HK. Int J Food Sci Nutr. 2006 Nov-Dec;57(7-8):546-55. PMID: 17162333.

Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders. Rodriguez MC, MacDonald JR, Mahoney DJ, Parise G, Beal MF, Tarnopolsky MA. Muscle Nerve. 2007 Feb;35(2):235-42. PMID: 17080429.

Clinical response of myelodysplastic syndromes patients to treatment with coenzyme Q10. Galili N, Sechman EV, Cerny J, Mehdi M, Mumtaz M, Westervelt P, Maguire J, Raza A. Leuk Res. 2007 Jan;31(1):19-26. Epub 2006 Oct 24. PMID: 17064768.

Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients. Shin MJ, Chung N, Lee JH, Jang Y, Park E, Jeon KI, Chung JH, Seo BY. Int J Cardiol. 2007 May 31;118(2):173-7. Epub 2006 Sep 26. PMID: 17005272.

Coenzyme Q10 and exercise training in chronic heart failure. Belardinelli R, Muçaj A, Lacalaprice F, Solenghi M, Seddaiu G, Principi F, Tiano L, Littarru GP. Eur Heart J. 2006 Nov;27(22):2675-81. Epub 2006 Aug 1. PMID: 16882678.

Coenzyme Q10 supplementation reduces corticosteroids dosage in patients with bronchial asthma. Gvozdjáková A, Kucharská J, Bartkovjaková M, Gazdíková K, Gazdík FE. Biofactors. 2005;25(1-4):235-40. PMID: 16873952.

Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men. Singh RB, Niaz MA, Kumar A, Sindberg CD, Moesgaard S, Littarru GP. Biofactors. 2005;25(1-4):219-24. PMID: 16873950.

Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure. Belardinelli R, Muçaj A, Lacalaprice F, Solenghi M, Principi F, Tiano L, Littarru GP. Biofactors. 2005;25(1-4):137-45. PMID: 16873938.

Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Berthold HK, Naini A, Di Mauro S, Hallikainen M, Gylling H, Krone W, Gouni-Berthold I. Drug Saf. 2006;29(8):703-12. PMID: 16872244.

Experience in coenzyme Q10 application in complex therapy of coronary heart disease with dyslipidemia. Belaia OL, Kalmykova VI, Ivanova LA, Kochergina LG. Klin Med (Mosk). 2006;84(5):59-62. Russian. PMID: 16827283.

Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial. Miles MV, Patterson BJ, Schapiro MB, Hickey FJ, Chalfonte-Evans M, Horn PS, Hotze SL. Pediatr Neurol. 2006 Jul;35(1):30-7. PMID: 16814082.

HPLC method for simultaneous determination of retinol, alpha-tocopherol and coenzyme Q10 in human plasma. Karpińska J, Mikołuć B, Motkowski R, Piotrowska-Jastrzebska J. J Pharm Biomed Anal. 2006 Sep 18;42(2):232-6. Epub 2006 Jun 9. PMID: 16765550.

Effects of fenofibrate therapy on plasma ubiquinol-10 and ubiquinone-10 levels in Japanese patients with hyperlipidemia and type 2 diabetes mellitus. Asano A, Kobayashi J, Murase Y, Nohara A, Kawashiri MA, Inazu A, Shimizu M, Mabuchi H. Pharmacotherapy. 2006 Apr;26(4):447-51. PMID: 16553501.

A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS. Levy G, Kaufmann P, Buchsbaum R, Montes J, Barsdorf A, Arbing R, Battista V, Zhou X, Mitsumoto H, Levin B, Thompson JL. Neurology. 2006 Mar 14;66(5):660-3. PMID: 16534103.

Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Ikematsu H, Nakamura K, Harashima S, Fujii K, Fukutomi N. Regul Toxicol Pharmacol. 2006 Apr;44(3):212-8. Epub 2006 Jan 23. PMID: 16431002.

The effect of coenzyme Q10 on idiopathic chronic dilated cardiomyopathy in children. Soongswang J, Sangtawesin C, Durongpisitkul K, Laohaprasitiporn D, Nana A, Punlee K, Kangkagate C. Pediatr Cardiol. 2005 Jul-Aug;26(4):361-6. PMID: 16374685.

Effects of dietary coenzyme Q10 supplementation on hepatic mitochondrial function and the activities of respiratory chain-related enzymes in ascitic broiler chickens. Geng AL, Guo YM. Br Poult Sci. 2005 Oct;46(5):626-34. PMID: 16359119.

Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS. Ferrante KL, Shefner J, Zhang H, Betensky R, O'Brien M, Yu H, Fantasia M, Taft J, Beal MF, Traynor B, Newhall K, Donofrio P, Caress J, Ashburn C, Freiberg B, O'Neill C, Paladenech C, Walker T, Pestronk A, Abrams B, Florence J, Renna R, Schierbecker J, Malkus B, Cudkowicz M. Neurology. 2005 Dec 13;65(11):1834-6. PMID: 16344537.

Muscle coenzyme Q10 level in statin-related myopathy. Lamperti C, Naini AB, Lucchini V, Prelle A, Bresolin N, Moggio M, Sciacco M, Kaufmann P, DiMauro S. Arch Neurol. 2005 Nov;62(11):1709-12. PMID: 16286544.

Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation. Zhou S, Zhang Y, Davie A, Marshall-Gradisnik S, Hu H, Wang J, Brushett D. J Sports Med Phys Fitness. 2005 Sep;45(3):337-46. PMID: 16230985.

A new Coenzyme Q10 tablet-grade formulation (all-Q) is bioequivalent to Q-Gel and both have better bioavailability properties than Q-SorB. Ullmann U, Metzner J, Schulz C, Perkins J, Leuenberger B. J Med Food. 2005 Fall;8(3):397-9. PMID: 16176154.

The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Witte KK, Nikitin NP, Parker AC, von Haehling S, Volk HD, Anker SD, Clark AL, Cleland JG. Eur Heart J. 2005 Nov;26(21):2238-44. Epub 2005 Aug 4. PMID: 16081469.

Seminal antioxidants in humans: preoperative and postoperative evaluation of coenzyme Q10 in varicocele patients. Mancini A, Milardi D, Conte G, Festa R, De Marinis L, Littarru GP. Horm Metab Res. 2005 Jul;37(7):428-32. PMID: 16034715.

Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Feher J, Kovacs B, Kovacs I, Schveoller M, Papale A, Balacco Gabrieli C. Ophthalmologica. 2005 May-Jun;219(3):154-66. PMID: 15947501.

Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. Mabuchi H, Higashikata T, Kawashiri M, Katsuda S, Mizuno M, Nohara A, Inazu A, Koizumi J, Kobayashi J. J Atheroscler Thromb. 2005;12(2):111-9. PMID: 15942122.

Possible role of ubiquinone in the treatment of massive hypertriglyceridemia resistant to PUFA and fibrates. Cicero AF, Derosa G, Miconi A, Laghi L, Nascetti S, Gaddi A. Biomed Pharmacother. 2005 Jul;59(6):312-7. PMID: 15932792.

Cognitive performance in relation to vitamin status in healthy elderly German women-the effect of 6-month multivitamin supplementation. Wolters M, Hickstein M, Flintermann A, Tewes U, Hahn A. Prev Med. 2005 Jul;41(1):253-9. Epub 2005 Jan 6. PMID: 15917019.

Prospective observational study of treatments for unexplained chronic fatigue. Bentler SE, Hartz AJ, Kuhn EM. J Clin Psychiatry. 2005 May;66(5):625-32. PMID: 15889950.

Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up. Hart PE, Lodi R, Rajagopalan B, Bradley JL, Crilley JG, Turner C, Blamire AM, Manners D, Styles P, Schapira AH, Cooper JM. Arch Neurol. 2005 Apr;62(4):621-6. PMID: 15824263.

Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study. Hoenjet KM, Dagnelie PC, Delaere KP, Wijckmans NE, Zambon JV, Oosterhof GO. Eur Urol. 2005 Apr;47(4):433-9; discussion 439-40. Epub 2005 Jan 19. PMID: 15774238.

A placebo-controlled screening trial of olanzapine, valproate, and coenzyme Q10/L-carnitine for the treatment of cocaine dependence. Reid MS, Casadonte P, Baker S, Sanfilipo M, Braunstein D, Hitzemann R, Montgomery A, Majewska D, Robinson J, Rotrosen J. Addiction. 2005 Mar;100 Suppl 1:43-57. PMID: 15730349.

Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Sándor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J. Neurology. 2005 Feb 22;64(4):713-5. PMID: 15728298.

Endothelium-ameliorating effects of statin therapy and coenzyme Q10 reductions in chronic heart failure. Strey CH, Young JM, Molyneux SL, George PM, Florkowski CM, Scott RS, Frampton CM. Atherosclerosis. 2005 Mar;179(1):201-6. Epub 2004 Dec 29. PMID: 15721028.

Influence of coenzyme Q(10) and cerivastatin on the flow-mediated vasodilation of the brachial artery: results of the ENDOTACT study. Kuettner A, Pieper A, Koch J, Enzmann F, Schroeder S. Int J Cardiol. 2005 Feb 28;98(3):413-9. PMID: 15708173.

Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. Rosenfeldt F, Marasco S, Lyon W, Wowk M, Sheeran F, Bailey M, Esmore D, Davis B, Pick A, Rabinov M, Smith J, Nagley P, Pepe S. J Thorac Cardiovasc Surg. 2005 Jan;129(1):25-32. PMID: 15632821.

Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts. Murashima M, Watanabe S, Zhuo XG, Uehara M, Kurashige A. Biofactors. 2004;22(1-4):271-5. PMID: 15630296.

Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A. Am J Cardiol. 2004 Nov 15;94(10):1306-10. PMID: 15541254.

Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study. Damian MS, Ellenberg D, Gildemeister R, Lauermann J, Simonis G, Sauter W, Georgi C. Circulation. 2004 Nov 9;110(19):3011-6. Epub 2004 Nov 1. PMID: 15520321.

Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Shults CW, Flint Beal M, Song D, Fontaine D. Exp Neurol. 2004 Aug;188(2):491-4. PMID: 15246848.

Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Berman M, Erman A, Ben-Gal T, Dvir D, Georghiou GP, Stamler A, Vered Y, Vidne BA, Aravot D. Clin Cardiol. 2004 May;27(5):295-9. PMID: 15188947.

Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders. Marriage BJ, Clandinin MT, Macdonald IM, Glerum DM. Mol Genet Metab. 2004 Apr;81(4):263-72. PMID: 15059613.

Neuroprotection becomes reality: changing times for cerebral resuscitation. Damian MS. Adv Exp Med Biol. 2004;550:143-50.  PMID: 15053432.

Coenzyme Q10-containing composition (Immugen) protects against occupational and environmental stress in workers of the gas and oil industry. Korkina L, Deeva I, Ibragimova G, Shakula A, Luci A, De Luca C. Biofactors. 2003;18(1-4):245-54. PMID: 14695940.

Serum coenzyme Q10 concentrations in healthy men supplemented with 30 mg or 100 mg coenzyme Q10 for two months in a randomised controlled study. Zita C, Overvad K, Mortensen SA, Sindberg CD, Moesgaard S, Hunter DA. Biofactors. 2003;18(1-4):185-93. PMID: 14695934.

Only transient increase of serum CoQ subset 10 during long-term CoQ10 therapy in mitochondrial ophthalmoplegia. Hanisch F, Zierz S. Eur J Med Res. 2003 Nov 12;8(11):485-91. PMID: 14644702.

Caudate volume as an outcome measure in clinical trials for Huntington's disease: a pilot study. Aylward EH, Rosenblatt A, Field K, Yallapragada V, Kieburtz K, McDermott M, Raymond LA, Almqvist EW, Hayden M, Ross CA. Brain Res Bull. 2003 Dec 15;62(2):137-41. PMID: 14638387.

The response of bile secretion and ubiquinone Q10 to hyperglycaemia in sheep. Wójcik M, Bobowiec R, Martelli F, Gazzano A. Pol J Vet Sci. 2003;6(3):183-8. PMID: 14510049.

Mitotropic compounds for the treatment of age-related macular degeneration. The metabolic approach and a pilot study. Feher J, Papale A, Mannino G, Gualdi L, Balacco Gabrieli C. Ophthalmologica. 2003 Sep-Oct;217(5):351-7. PMID: 12913326.

Effect of taurine and coenzyme Q10 in patients with acute myocardial infarction. Singh RB, Kartikey K, Charu AS, Niaz MA, Schaffer S. Adv Exp Med Biol. 2003;526:41-8. PMID: 12908582.

Plasma ubiquinone status and response to six-month supplementation combined with multivitamins in healthy elderly women--results of a randomized, double-blind, placebo-controlled study. Wolters M, Hahn A. Int J Vitam Nutr Res. 2003 May;73(3):207-14. PMID: 12847998.

Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Singh RB, Neki NS, Kartikey K, Pella D, Kumar A, Niaz MA, Thakur AS. Mol Cell Biochem. 2003 Apr;246(1-2):75-82. PMID: 12841346.

Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial. Engelsen J, Nielsen JD, Hansen KF. Ugeskr Laeger. 2003 Apr 28;165(18):1868-71. Danish. PMID: 12772396.

Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes. Playford DA, Watts GF, Croft KD, Burke V. Atherosclerosis. 2003 May;168(1):169-79. PMID: 12732401.

Blood mononuclear cell coenzyme Q10 concentration and mitochondrial respiratory chain succinate cytochrome-c reductase activity in phenylketonuric patients. Hargreaves IP, Heales SJ, Briddon A, Land JM, Lee PJ. J Inherit Metab Dis. 2002 Dec;25(8):673-9. PMID: 12705497.

Coenzyme Q10: another biochemical alteration linked to infertility in varicocele patients? Mancini A, Milardi D, Conte G, Bianchi A, Balercia G, De Marinis L, Littarru GP. Metabolism. 2003 Apr;52(4):402-6. PMID: 12701049.

Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease. Müller T, Büttner T, Gholipour AF, Kuhn W. Neurosci Lett. 2003 May 8;341(3):201-4. PMID: 12697283.

Cerebellar ataxia and coenzyme Q10 deficiency. Lamperti C, Naini A, Hirano M, De Vivo DC, Bertini E, Servidei S, Valeriani M, Lynch D, Banwell B, Berg M, Dubrovsky T, Chiriboga C, Angelini C, Pegoraro E, DiMauro S. Neurology. 2003 Apr 8;60(7):1206-8. PMID: 12682339.

Relative bioavailability and antioxidant potential of two coenzyme q10 preparations. Kurowska EM, Dresser G, Deutsch L, Bassoo E, Freeman DJ. Ann Nutr Metab. 2003;47(1):16-21. PMID: 12624483.

Attenuation of blood parameters in smokers and non-smokers after intake of a complex food additive. Hippeli S, Dornisch K, Brink M, Lorenz R, Jeschke D, Elstner EF. Z Naturforsch C. 2003 Jan-Feb;58(1-2):119-27. PMID: 12622238.

Differences in coenzyme Q10 content in deltoid and quadriceps muscles. Benoist JF, Rigal O, Nivoche Y, Martin C, Biou D, Lombès A. Clin Chim Acta. 2003 Mar;329(1-2):147-8.  PMID: 12589978.

Glucocortioid treatment for heroin-induced spongiform leucoencephalopathy: a clinical controlled study. Zhou L, Lu BX, Yin J, Luo YF, Wang Q, Liu XJ. Di Yi Jun Yi Da Xue Xue Bao. 2003 Feb;23(2):172-4. Chinese. PMID: 12581974.

Observation on collaborative treatment of dilated cardiomyopathy. Yang YZ, Chen RZ, Zhang JN. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Apr;21(4):254-6. Chinese. PMID: 12577349.

Comparative bioavailability of two novel coenzyme Q10 preparations in humans. Joshi SS, Sawant SV, Shedge A, Halpner AD. Int J Clin Pharmacol Ther. 2003 Jan;41(1):42-8. PMID: 12564745.

Total coenzyme Q10 concentrations in Asian men following multiple oral 50-mg doses administered as coenzyme Q10 sustained release tablets or regular tablets. Lu WL, Zhang Q, Lee HS, Zhou TY, Sun HD, Zhang DW, Zheng L, Lee M, Wong SM. Biol Pharm Bull. 2003 Jan;26(1):52-5. PMID: 12520172.

Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Eur J Clin Nutr. 2002 Nov;56(11):1137-42. PMID: 12428181.

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M; Parkinson Study Group. Arch Neurol. 2002 Oct;59(10):1541-50. PMID: 12374491.

Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Engelsen J, Nielsen JD, Winther K. Thromb Haemost. 2002 Jun;87(6):1075-6.  PMID: 12083489.

Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. Jeejeebhoy F, Keith M, Freeman M, Barr A, McCall M, Kurian R, Mazer D, Errett L. Am Heart J. 2002 Jun;143(6):1092-100. PMID: 12075268.

Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle. Linnane AW, Kopsidas G, Zhang C, Yarovaya N, Kovalenko S, Papakostopoulos P, Eastwood H, Graves S, Richardson M. Free Radic Res. 2002 Apr;36(4):445-53. PMID: 12069109.

Coenzyme Q10: absorption, antioxidative properties, determinants, and plasma levels. Kaikkonen J, Tuomainen TP, Nyyssonen K, Salonen JT. Free Radic Res. 2002 Apr;36(4):389-97. PMID: 12069102.

An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome. Lister RE. J Int Med Res. 2002 Mar-Apr;30(2):195-9. PMID: 12025528.

The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium. Rosenfeldt FL, Pepe S, Linnane A, Nagley P, Rowland M, Ou R, Marasco S, Lyon W. Biogerontology. 2002;3(1-2):37-40. PMID: 12014839.

Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients. Rosenfeldt FL, Pepe S, Linnane A, Nagley P, Rowland M, Ou R, Marasco S, Lyon W, Esmore D. Ann N Y Acad Sci. 2002 Apr;959:355-9; discussion 463-5. PMID: 11976209.

Open label trial of coenzyme Q10 as a migraine preventive. Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD. Cephalalgia. 2002 Mar;22(2):137-41. PMID: 11972582.

Modulation of apoptosis and improved redox metabolism with the use of a new antioxidant formula. Mosca L, Marcellini S, Perluigi M, Mastroiacovo P, Moretti S, Famularo G, Peluso I, Santini G, De Simone C. Biochem Pharmacol. 2002 Apr 1;63(7):1305-14. PMID: 11960607.

Therapeutic trial in the first three Asian cases of ethylmalonic encephalopathy: response to riboflavin. Yoon HR, Hahn SH, Ahn YM, Jang SH, Shin YJ, Lee EH, Ryu KH, Eun BL, Rinaldo P, Yamaguchi S. J Inherit Metab Dis. 2001 Dec;24(8):870-3. PMID: 11916321.

Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke V. Diabetologia. 2002 Mar;45(3):420-6. PMID: 11914748.

Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. Burke BE, Neuenschwander R, Olson RD. South Med J. 2001 Nov;94(11):1112-7. PMID: 11780680.

Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress. Cornelli U, Terranova R, Luca S, Cornelli M, Alberti A. J Nutr. 2001 Dec;131(12):3208-11. PMID: 11739867.

Similar therapeutic serum levels attained with emulsified and oil-based preparations of coenzyme Q10. Lyon W, Van den Brink O, Pepe S, Wowk M, Marasco S, Rosenfeldt FL. Asia Pac J Clin Nutr. 2001;10(3):212-5. PMID: 11708311.

A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Huntington Study Group. Neurology. 2001 Aug 14;57(3):397-404. PMID: 11502903.

The effect of pravastatin and atorvastatin on coenzyme Q10. Bleske BE, Willis RA, Anthony M, Casselberry N, Datwani M, Uhley VE, Secontine SG, Shea MJ. Am Heart J. 2001 Aug;142(2):E2. PMID: 11479481.

Effect on life span and membrane protein in red blood cells by integrated medicine therapy on chronic aplastic anemia. Wang S, Zhang S, Li J. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 May;18(5):262-4. Chinese. PMID: 11477920.

Effect of coenzyme Q10 in patients with kidney diseases. Gazdíková K, Gvozdjáková A, Kucharská J, Spustová V, Braunová Z, Dzúrik R. Cas Lek Cesk. 2001 May 24;140(10):307-10. Slovak. PMID: 11411060.

Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-alpha-tocopherol in mildly hypercholesterolemic subjects: a randomized placebo-controlled clinical study. Kaikkonen J, Nyyssönen K, Tomasi A, Iannone A, Tuomainen TP, Porkkala-Sarataho E, Salonen JT. Free Radic Res. 2000 Sep;33(3):329-40. PMID: 10993487.

Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects. Bonetti A, Solito F, Carmosino G, Bargossi AM, Fiorella PL. J Sports Med Phys Fitness. 2000 Mar;40(1):51-7. PMID: 10822909.

The effect of coenzyme Q10 in patients with congestive heart failure. Khatta M, Alexander BS, Krichten CM, Fisher ML, Freudenberger R, Robinson SW, Gottlieb SS. Ann Intern Med. 2000 Apr 18;132(8):636-40. PMID: 10766682.

Intensification in vivo of free radical oxidation of low density lipoproteins in plasma from patients with myocardial ischemia treated by HMG-CoA-reductase pravastatin and suppression of lipid peroxidation by ubiquinone Q10. Lankin VZ, Tikhaze AK, Kaminnaia VI, Kaminnyĭ AI, Konovalova GG, Kukharchuk VV. Biull Eksp Biol Med. 2000 Feb;129(2):176-9. Russian. PMID: 10732240.

Effects of multivitamin/mineral supplementation, at nutritional doses, on plasma antioxidant status and DNA damage estimated by sister chromatid exchanges in lymphocytes in pregnant women. Park E, Wagenbichler P, Elmadfa I. Int J Vitam Nutr Res. 1999 Nov;69(6):396-402. PMID: 10642897.

Oxidative stress and anti-oxidant metabolites in patients with hyperthyroidism: effect of treatment. Bianchi G, Solaroli E, Zaccheroni V, Grossi G, Bargossi AM, Melchionda N, Marchesini G. Horm Metab Res. 1999 Nov;31(11):620-4. PMID: 10598831.

The antioxidant protection of the heart by coenzyme Q10 in stable stenocardia of effort. Kogan AKh, Syrkin AL, Drinitsina SV, Kokanova IV. Patol Fiziol Eksp Ter. 1999 Oct-Dec;(4):16-9. Russian. PMID: 10598457.

Case report: oral antioxidant therapy for the treatment of primary biliary cirrhosis: a pilot study. Watson JP, Jones DE, James OF, Cann PA, Bramble MG. J Gastroenterol Hepatol. 1999 Oct;14(10):1034-40. PMID: 10530501.

Coenzyme Q10 administration increases antibody titer in hepatitis B vaccinated volunteers--a single blind placebo-controlled and randomized clinical study. Barbieri B, Lund B, Lundström B, Scaglione F. Biofactors. 1999;9(2-4):351-7. PMID: 10416052.

Monounsaturated diet lowers LDL oxidisability in type IIb and type IV dyslipidemia without affecting coenzyme Q10 and vitamin E contents. Svegliati Baroni S, Amelio M, Fiorito A, Gaddi A, Littarru G, Battino M. Biofactors. 1999;9(2-4):325-30. PMID: 10416048.

The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. Eriksson JG, Forsén TJ, Mortensen SA, Rohde M. Biofactors. 1999;9(2-4):315-8. PMID: 10416046.

Coenzyme Q10 treatment in serious heart failure. Munkholm H, Hansen HH, Rasmussen K. Biofactors. 1999;9(2-4):285-9. PMID: 10416042.

Effects of coenzyme Q10 on myocardial protection during cardiac valve replacement and scavenging free radical activity in vitro. Zhou M, Zhi Q, Tang Y, Yu D, Han J. J Cardiovasc Surg (Torino). 1999 Jun;40(3):355-61. PMID: 10412920.

Effect of treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients. Miyake Y, Shouzu A, Nishikawa M, Yonemoto T, Shimizu H, Omoto S, Hayakawa T, Inada M. Arzneimittelforschung. 1999 Apr;49(4):324-9. PMID: 10337451.

Antiglutamate therapies in Huntington's disease. Kieburtz K. J Neural Transm Suppl. 1999;55:97-102. Review. PMID: 10335496.

No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Nielsen AN, Mizuno M, Ratkevicius A, Mohr T, Rohde M, Mortensen SA, Quistorff B. Int J Sports Med. 1999 Apr;20(3):154-8. PMID: 10333091.

Low brain intracellular free magnesium in mitochondrial cytopathies. Barbiroli B, Iotti S, Cortelli P, Martinelli P, Lodi R, Carelli V, Montagna P. J Cereb Blood Flow Metab. 1999 May;19(5):528-32. PMID: 10326720.

Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus. Henriksen JE, Andersen CB, Hother-Nielsen O, Vaag A, Mortensen SA, Beck-Nielsen H. Diabet Med. 1999 Apr;16(4):312-8. PMID: 10220205.

Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. Singh RB, Niaz MA, Rastogi SS, Shukla PK, Thakur AS. J Hum Hypertens. 1999 Mar;13(3):203-8. PMID: 10204818.

Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role. Singh RB, Niaz MA. Int J Cardiol. 1999 Jan;68(1):23-9. PMID: 10077397.

Effect of coenzyme Q10 in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): evaluation by noninvasive tissue oximetry. Abe K, Matsuo Y, Kadekawa J, Inoue S, Yanagihara T. J Neurol Sci. 1999 Jan 1;162(1):65-8. PMID: 10064171.

Determinants of plasma coenzyme Q10 in humans. Kaikkonen J, Nyyssönen K, Tuomainen TP, Ristonmaa U, Salonen JT. FEBS Lett. 1999 Jan 25;443(2):163-6. PMID: 9989597.

Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Singh RB, Wander GS, Rastogi A, Shukla PK, Mittal A, Sharma JP, Mehrotra SK, Kapoor R, Chopra RK. Cardiovasc Drugs Ther. 1998 Sep;12(4):347-53. PMID: 9825179.

The chemoprotective effect of coenzyme Q on lipids in the paint and lacquer industry workers. Długosz A, Sawicka E. Int J Occup Med Environ Health. 1998;11(2):153-63. PMID: 9753894.

The use of the antioxidant coenzyme Q10 as a cytoprotection variant in ischemic heart disease. Syrkin AL, Kogan AKh, Drinitsina SV, Kuznetsov AB, Pechorina EA, Frenkel' EE, Kuleshova NN, Golovnia LD. Klin Med (Mosk). 1998;76(7):24-8. Russian. PMID: 9742773.

Effect of combined coenzyme Q10 and d-alpha-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners. Kaikkonen J, Kosonen L, Nyyssönen K, Porkkala-Sarataho E, Salonen R, Korpela H, Salonen JT. Free Radic Res. 1998 Jul;29(1):85-92. PMID: 9733025.

The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation. Suzuki S, Hinokio Y, Ohtomo M, Hirai M, Hirai A, Chiba M, Kasuga S, Satoh Y, Akai H, Toyota T. Diabetologia. 1998 May;41(5):584-8. PMID: 9628277.

Ineffectiveness of oral coenzyme Q10 supplementation in 3-methylglutaconic aciduria, type 3. Costeff H, Apter N, Elpeleg ON, Prialnic M, Böhles HJ. Brain Dev. 1998 Jan;20(1):33-5. PMID: 9533558.

Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants. Brude IR, Drevon CA, Hjermann I, Seljeflot I, Lund-Katz S, Saarem K, Sandstad B, Solvoll K, Halvorsen B, Arnesen H, Nenseter MS. Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2576-88. PMID: 9409230.

Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? Weston SB, Zhou S, Weatherby RP, Robson SJ. Int J Sport Nutr. 1997 Sep;7(3):197-206. PMID: 9286743.

Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy. Barbiroli B, Frassineti C, Martinelli P, Iotti S, Lodi R, Cortelli P, Montagna P. Cell Mol Biol (Noisy-le-grand). 1997 Jul;43(5):741-9. PMID: 9298596.

The clinical and hemodynamic effects of coenzyme Q10 in congestive cardiomyopathy. Sacher HL, Sacher ML, Landau SW, Kersten R, Dooley F, Sacher A, Sacher M, Dietrick K, Ichkhan K. Am J Ther. 1997 Feb-Mar;4(2-3):66-72. PMID: 10423594.

No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers. Priemé H, Loft S, Nyyssönen K, Salonen JT, Poulsen HE. Am J Clin Nutr. 1997 Feb;65(2):503-7. PMID: 9022536.